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It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends. The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing. Metabolic loss tracks weight regain

Dependence and Withdrawal: Risk of psychological dependence and withdrawal symptoms upon cessation

These usually resolve within 2448 hours without intervention

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Investigated for stress response and cognitive function pathways